Innovation
The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear.
To evaluate the effects of a 12-month partially supervised PA intervention using motivational feedback.
Evaluation System
The primary endpoint was the change in the predicted percentage of FEV1 (ΔFEV1) at 6 months. Secondary outcomes included PA, exercise capacity, exercise motivation, time to first exacerbation and exacerbation rates, quality of life, anxiety, depression, stress and blood glucose control. After 6 months, ΔFEV1 was significantly higher in the control group compared to the intervention group (2.70% of predicted [95% confidence interval, 0.13-5.26]; P = 0.04). The intervention group reported an increase in vigorous PA compared to the control group at each visit, had greater exercise capacity at 6 and 12 months, and greater PA at 12 months. No effects on other secondary outcomes were observed.
Assessment
ACTIVATE-FQ (cystic fibrosis) increased vigorous physical activity and exercise capacity, with effects that were maintained over the following 6 months, but resulted in a better FEV1 in the control group.
References
Hebestreit, H., Kriemler, S., Schindler, C., Stein, L., Karila, C., Urquhart, D. S., ... & Radtke, T. (2022). Effects of a partially supervised conditioning program in cystic fibrosis: an international multicenter, randomized controlled trial (ACTIVATE-CF). American journal of respiratory and critical care medicine, 205(3), 330-339.
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