The Breath project (Project Number: 2022-1-PL01-KA220-HED-000089283) has been Co-funded by the European Union. Views and opinions expressed are however those of the author or authors only and do not necessarily reflect those of the European Union or the Foundation for the Development of the Education System. Neither the European Union nor the entity providing the grant can be held responsible for them.

Effects of a partially supervised conditioning program on cystic fibrosis - an international multicenter, randomized, controlled trial (Active CF)

Choose one of the available languages:
Institution
University Hospitals Wurzburg
Institution Typology
University
Country
Germany
Description
Intervention design: At least 30 minutes of strengthening exercises and 2 hours of aerobic exercise per week. Details about the exercise intervention, structured motivational interviewing, exercise intensity prescription, activity counseling and individual training monitoring in an online diary are provided in the online supplement. People involved: 117 participants, Intervention, n = 60 and Control Group, n = 57 Barriers identified: The barriers reported by participants were not wanting to be randomized to an intense physical activity (PA) program due to other priorities (e.g. school exams) and the 50% chance of being randomized to the control group, despite knowing about the importance of regular PA through the study information. Sustainability: A supervised exercise intervention in FQ (5) showed that 3 × 30 minutes of aerobic training or muscle strengthening training per week could significantly improve FEV1 in the 6 months following the intervention. An additional two hours of vigorous PA per week in our intervention group participants should therefore be sufficient to improve FEV1. Our results indicate that a sharp increase in vigorous PA (most likely) represents the wrong approach to improving lung health for the majority of people with CF who are relatively sedentary. Transferability: Given the multiple benefits of PA established in various populations, healthcare providers are advised to motivate people with CF to be physically active, without pressure but with appropriate supervision, including setting individual goals with the aim of building positive long-term activity behavior.
Disease
Cystic Fibrosis
Activity level
Medium
Activity Typology
Rehabilitation section-based activities, Home-based activities
Motivation Tools
Not available

Innovation
The long-term effects of vigorous physical activity (PA) on lung function in cystic fibrosis are unclear.



To evaluate the effects of a 12-month partially supervised PA intervention using motivational feedback.

Evaluation System
The primary endpoint was the change in the predicted percentage of FEV1 (ΔFEV1) at 6 months. Secondary outcomes included PA, exercise capacity, exercise motivation, time to first exacerbation and exacerbation rates, quality of life, anxiety, depression, stress and blood glucose control. After 6 months, ΔFEV1 was significantly higher in the control group compared to the intervention group (2.70% of predicted [95% confidence interval, 0.13-5.26]; P = 0.04). The intervention group reported an increase in vigorous PA compared to the control group at each visit, had greater exercise capacity at 6 and 12 months, and greater PA at 12 months. No effects on other secondary outcomes were observed.

Assessment
ACTIVATE-FQ (cystic fibrosis) increased vigorous physical activity and exercise capacity, with effects that were maintained over the following 6 months, but resulted in a better FEV1 in the control group.
References
Hebestreit, H., Kriemler, S., Schindler, C., Stein, L., Karila, C., Urquhart, D. S., ... & Radtke, T. (2022). Effects of a partially supervised conditioning program in cystic fibrosis: an international multicenter, randomized controlled trial (ACTIVATE-CF). American journal of respiratory and critical care medicine, 205(3), 330-339.doi.org/10.1164/rccm.202106-1419OC" target="_blank">doi.org/10.1164/rccm.202106-1419OC" target="_blank">doi.org/10.1164/rccm.202106-1419OC" target="_blank">doi.org/10.1164/rccm.202106-1419OC

Log in to comment >>

Alejandro Galán Mercant, Fisioterapia Funcional Fi - Spain (ES)
Artículo de interés, es importante el desarrollo y prescripción de ejercicio de manera supervisada e individualizada.

Bruno Ferreira, ESS - IPS - Portugal (PT)
Interesting approach. Future studies could tailor exercise intensity to individual patient profiles to maximize both physical capacity and lung health.