The Breath project (Project Number: 2022-1-PL01-KA220-HED-000089283) has been Co-funded by the European Union. Views and opinions expressed are however those of the author or authors only and do not necessarily reflect those of the European Union or the Foundation for the Development of the Education System. Neither the European Union nor the entity providing the grant can be held responsible for them.

Oxidative Stress and Total Phenolics Concentration in COPD Patients—The Effect of Exercises: A Randomized Controlled Trial

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Institution
Department of Physiology and Biochemistry, Poznan University of Physical Education, Poznan, Poland
Institution Typology
University
Country
Poland
Description
Intervention design: The study focused on the impact of endurance training in a pulmonary rehabilitation program for COPD patients on the imbalance between prooxidants and antioxidants in their bodies. People involved: 32 patients with COPD, researchers, and healthcare professionals from the Wielkopolska Centre of Pulmonology and Thoracosurgery. Identified barriers: Managing the intensity of exercise to avoid exacerbation of COPD symptoms. Sustainability: The study suggests endurance training as a sustainable component of rehabilitation without aggravating oxidative stress. Transferability: The intervention can be applied in other pulmonary rehabilitation programs with similar patient profiles.
Disease
COPD
Activity level
Medium
Activity Typology
Rehabilitation section-based activities
Motivation Tools
Not available
Innovation
The study highlights the use of biochemical markers such as allantoin as a more sensitive indicator of free radical changes, suggesting new avenues for assessing the impact of rehabilitation on oxidative stress
Evaluation System
Quantifiable results: Spirometric parameters (FEV1/FVC), VO2max, distance covered in treadmill tests, and concentrations of oxidative stress markers (allantoin, FRAP, TBARS, total phenolics).
Presence of comparison group: Yes, a control group was included that received standard treatment without endurance training
Assessment
The practice is considered good as it demonstrated that endurance training in COPD patients did not exacerbate oxidative stress and provided positive effects on physical capacity and spirometric outcomes.
References
Domaszewska K, Górna S, Pietrzak M, Podgórski T. Oxidative Stress and Total Phenolics Concentration in COPD Patients-The Effect of Exercises: A Randomized Controlled Trial. Nutrients. 2022;14(9):1947. Published 2022 May 6. doi:10.3390/nu14091947
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